| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-614 | |
| Phytochemical name or plant extracts | Anacardic acid | |
| PMID | 26990649 | |
| Literature evidence | Since mitochondrial-targeted anticancer therapy (mitocans) may be useful in breast cancer, we examined the effect of anacardic acid on cellular bioenergetics and OXPHOS pathway proteins in breast cancer cells modeling progression to endocrine-independence: MCF-7 estrogen receptor ? (ER?)+ endocrine-sensitive, LCC9 and LY2 ER?+, endocrine-resistant, and MDA-MB-231 triple negative breast cancer (TNBC) cells. | |
| IUPAC name | 2-hydroxy-6-pentadecylbenzoic acid | |
| Phytochemicals’ class or type of plant extracts | Phenolic acid | |
| Source of phytochemicals or plant Extracts | Anacardium occidentale | |
| Geographical availability | Bolivia, Brazil North, Brazil Northeast, Brazil Southeast, Brazil West-Central, Colombia, Ecuador, Guyana, Peru, Suriname, Trinidad-Tobago, Venezuela | |
| Plant parts | Nutshell | |
| Other cancers | Breast cancer | |
| Target gene or protein | SCD, INSIG1,TGM2, PDK4, GPR176, ZBT20, GRP78, Hsp70, CDK-4, MMP9, Bcl-2, Mcl-1 , miR-378g, Cyclin D1, MYC, c-FOS, PPARγ, SIN3 | |
| Gene or Protein evidence | Only six genes were commonly altered by AnAc in both cell lines: SCD, INSIG1, and TGM2 were decreased and PDK4, GPR176, and ZBT20 were increased. Regulation of the key Hsp90-dependent tumor-related molecules or endoplasmic reticulum stress (ERS) related molecules, such as GRP78, Hsp70, CDK-4, MMP-9, Bcl-2, and Mcl-1 by AA may be related to these effects. AnAc reduced miR-378g that targets VIM (vimentin) and VIM mRNA transcript expression was increased in AnAc-treated MCF-7 cells, suggesting a reciprocal relationship. The pathways modulated by these AnAc-regulated miRNAs suggest that key nodal molecules, e.g., Cyclin D1, MYC, c-FOS, PPARγ, and SIN3, are targets of AnAc activity. | |
| Target pathways | VEGF signaling pathway | |
| IC50 | 13.5 µM against MCF-7 35 µM against MDA-MB-231 | |
| Potency | Anacardic acid (AnAc) is a dietary phenolic lipid that inhibits both MCF-7 estrogen receptor α (ERα) positive and MDA-MB-231 triple negative breast cancer (TNBC) cell proliferation with IC50s of 13.5 and 35 μM, respectively. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | Taken together, our results suggest that AA shows potential as a possible new drug for therapy of TNBC. | |
| PubChem ID | 167551 | |
| Additional PMIDs | 25788052 28886127 30210681 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:319068-2 | |
| Safety | NA |