| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2007 | |
| Phytochemical name or plant extracts | Amplexicaule A | |
| PMID | 26943775 | |
| Literature evidence | Chemotherapy is the main treatment for patients with breast cancer metastases, but natural alternatives have been receiving attention for their potential as novel anti-tumor reagents. | |
| IUPAC name | 3-o-[α-L-rhamnopyranosyl-(1-6)- β-D-Galactopyranose]-5,7,3′,4′-tetrahydroxy | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Polygonum amplexicaule D. Don var. sinense Forb | |
| Geographical availability | Afghanistan, China North-Central, China South-Central, China Southeast, East Himalaya, Nepal, Pakistan, West Himalaya | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3,-8,-9, PARP, MCL-1, Bcl-2 | |
| Gene or Protein evidence | APA increased levels of cleaved caspase-3,-8,-9 and PARP, which resulted from suppression of MCL-1 and BCL-2 expression in the cells. | |
| Target pathways | APA also inactivated the Akt/mTOR pathway in breast cancer cells. | |
| IC50 | NA | |
| Potency | Amplexicaule A exerts anti-tumor effects by inducing apoptosis in human breast cancer | |
| Cell line/ mice model | MCF-7, MDA-MB-435, Female Kunming nude mice | |
| Additional information | These data further support the notion that APA could potentially be an effective therapeutic agent for the treatment of breast cancer. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:2889941-4 | |
| Safety | NA |