| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-252 | |
| Phytochemical name or plant extracts | Ampelopsin E | |
| PMID | 31323836 | |
| Literature evidence | In conclusion, ampelopsin E reduced the invasiveness of MDA-MB-231 cells and was proven to be a potential alternative in treating TNBC. | |
| IUPAC name | 5-[(2S,3S,5R,6R)-3-(3,5-dihydroxyphenyl)-2,6-bis(4-hydroxyphenyl)-4-[(E)-2-(4-hydroxyphenyl)ethenyl]-2,3,5,6-tetrahydrofuro[3,2-f][1]benzofuran-5-yl]benzene-1,3-diol | |
| Phytochemicals’ class or type of plant extracts | Oligostilbene | |
| Source of phytochemicals or plant Extracts | Dryobalanops rappa | |
| Geographical availability | Borneo | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | PDGF, MMP2, MMP9, MMP14 | |
| Gene or Protein evidence | Strikingly in this study, ampelopsin E was able to halt migration, transmigration and invasion in MDA-MB-231 cells by reducing formation of invadopodia and its degradation capability through significant reduction (p < 0.05) in expression levels of PDGF, MMP2, MMP9 and MMP14. | |
| Target pathways | NA | |
| IC50 | 14.5 ± 0.71 μM at 72 h against MDA-MB-231 | |
| Potency | In conclusion, ampelopsin E reduced the invasiveness of MDA-MB-231 cells and was proven to be a potential alternative in treating TNBC. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, HT-29, A-549, HeLa, 3T3, MCF10A | |
| Additional information | In summary, this study highlighted the inhibitory effects of ampelopsin E towards the invasiveness of MDA-MB-231 breast carcinoma cells by significantly suppressing migration, invasion, invadopodia formation, gelatin degradation and invasion/invadopodia-related protein expressions such as PDGF, MMP2, MMP9 and MMP14. | |
| PubChem ID | 10439550 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:320819-1 | |
| Safety | NA |