| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-932 | |
| Phytochemical name or plant extracts | Ampelopsin C | |
| PMID | 30789269 | |
| Literature evidence | Overall, ampelopsins A and C extracted from Vitis thunbergii are both novel antimetastatic agents and potential therapeutic targets in patients with breast cancer. | |
| IUPAC name | 2-(3,5-dihydroxyphenyl)-3,9,17-tris(4-hydroxyphenyl)-8-oxapentacyclo[8.7.2.04,18.07,19.011,16]nonadeca-4(18),5,7(19),11(16),12,14-hexaene-5,13,15-triol | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Vitis thunbergii | |
| Geographical availability | China North-Central, China Southeast, Japan, Korea, Manchuria, Primorye, Taiwan, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | AXL, Dtk (TYRO3), EphA2, EphA6, Fyn, Hck, SRMS | |
| Gene or Protein evidence | Among the 71 proteins present on the human phosphoreceptor tyrosin kinase array, ampelopsin C decreased the phosphorylated protein level of AXL, Dtk (TYRO3), EphA2, EphA6, Fyn, Hck, and SRMS. | |
| Target pathways | PI3K/Akt and ERK pathways | |
| IC50 | 2.71 ± 0.21 μM against MDA-MB-231 at 72h | |
| Potency | However, at 24 h, ampelopsins A and C decreased cell metastasis significantly. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Treatment with high concentrations of ampelopsin A (30–50 μM) and ampelopsin C (3–5 μM) for 72 h resulted in increased cell death and suppression on the growth of MDA-MB-231 cells. | |
| PubChem ID | 182979 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:870799-1 | |
| Safety | NA |