| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-931 | |
| Phytochemical name or plant extracts | Ampelopsin A | |
| PMID | 30789269 | |
| Literature evidence | Overall, ampelopsins A and C extracted from Vitis thunbergii are both novel antimetastatic agents and potential therapeutic targets in patients with breast cancer. | |
| IUPAC name | (1S,8S,9R,16S)-8,16-bis(4-hydroxyphenyl)-15-oxatetracyclo[8.6.1.02,7.014,17]heptadeca-2(7),3,5,10(17),11,13-hexaene-4,6,9,12-tetrol | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Vitis thunbergii | |
| Geographical availability | China North-Central, China Southeast, Japan, Korea, Manchuria, Primorye, Taiwan, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | AKT | |
| Gene or Protein evidence | Treatment with ampelopsins A and C also decreased the expression of Akt phosphorylation | |
| Target pathways | NA | |
| IC50 | 38.75 ± 4.61 μM against MDA-MB-231 at 72h | |
| Potency | Overall, ampelopsins A and C extracted from Vitis thunbergii are both novel antimetastatic agents and potential therapeutic targets in patients with breast cancer. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Apoptotic cells after 48 and 72 h of treatment with 40 μM ampelopsin A were 44.23 and 78.22%, respectively. | |
| PubChem ID | 182999 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:870799-1 | |
| Safety | NA |