| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-797 | |
| Phytochemical name or plant extracts | Ampelopsin | |
| PMID | 26189300 | |
| Literature evidence | Ampelopsin (AMP), a novel flavonoid, has been shown to effectively inhibit the proliferation and induce apoptosis of some prostate cancer and breast cancer cell lines. | |
| IUPAC name | (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Ampelopsis grossedentata | |
| Geographical availability | China South-Central, China Southeast, Vietnam | |
| Plant parts | Stem, Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | p21, Cyclin A, CDK2, IκBα, NF-κB p65 , CD44, MRP1, β-catenin, KLF4 | |
| Gene or Protein evidence | The AMP blocked cells in the G0/G1 phase of the cell cycle. Furthermore, AMP increased p21(CIP1) expression but decreased cyclin A and CDK2 expression after AMP exposure. Notably, ampelopsin treatment significantly reduced the levels of the phosphorylated forms of IκBα and NF-κB p65, as well as the levels of tumor necrosis factor (TNF)-α-stimulated phosphorylation of IκBα and NF-κB p65. Importantly, ampelopsin displayed an inhibitory impact on the stemness features of MDA-MB-231/IR cells, demonstrated by decreases in mammosphere formation, the CD44+/CD24-/low population, aldehyde dehydrogenase activity, and the levels of stem cell markers (e.g., CD44, MRP1, β-catenin, and KLF4). | |
| Target pathways | TNF-α/NF-κB signaling axis, Mitochondrial Apoptosis Pathway, ROS generation and endoplasmic reticulum stress pathway. | |
| IC50 | 58 ± 3.84 µM against MDA-MB-231 | |
| Potency | The cell viability was reduced in a time- and dose-dependent manner after exposure to AMP atarangeof 20-100 μmol/L. For the treatment of AMP, increases of apoptotic index and rate were observed in MG-63 cells. | |
| Cell line/ mice model | MDA-MB-231, MDA-MB-231/IR | |
| Additional information | Our previous study has shown that ampelopsin (AMP), a flavonol mainly found in Ampelopsis grossedentata, could induce cell death in human breast cancer cells via reactive oxygen species generation and endoplasmic reticulum (ER) stress pathway. | |
| PubChem ID | 161557 | |
| Additional PMIDs | 34451892 31323836 26677700 25088800 28403777 26189300 24551210 34470980 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77142325-1 | |
| Safety | NA |