| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-638 | |
| Phytochemical name or plant extracts | Amorphophallus paeoniifolius extract | |
| PMID | 33034216 | |
| Literature evidence | Medicinal plants offer enormous possibilities in the quest of novel bioactive formulation for cancer therapy. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Hydroethanolic extract | |
| Source of phytochemicals or plant Extracts | Amorphophallus paeoniifolius | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, New Guinea, Northern Territory, Philippines, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vietnam | |
| Plant parts | Tuber | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Bax, Caspase 7, PARP | |
| Gene or Protein evidence | Annexin V-Cy3 staining suggested that APTE induced apoptosis in these cells which was further validated by attenuation of antiapoptotic Bcl-2 and induction of pro-apoptotic Bax, Caspase-7 expression and cleavage of PARP. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | APTE significantly reduced migration in both the cell lines, however, its effect on the inhibition of adhesion and invasion was higher in MDA-MB-231 cells. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | Overall, the study described the mechanism of anticancer activity of a common edible tuber A. paeoniifolius and contributes to growing list of naturally occurring chemo-preventive strategies. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60444138-2 | |
| Safety | NA |