| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-584 | |
| Phytochemical name or plant extracts | Amooranin | |
| PMID | 14503804 | |
| Literature evidence | Novel drug amooranin induces apoptosis through caspase activity in human breast carcinoma cell lines. | |
| IUPAC name | (4aS,6aS,6aS,6bR,8aR,12aS,14bS)-12a-(hydroxymethyl)-2,2,6a,6b,9,9-hexamethyl-10-oxo-3,4,5,6,6a,7,8,8a,11,12,13,14b-dodecahydro-1H-picene-4a-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Amoora rohituka | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, New Guinea, Nicobar Is., Philippines, Solomon Is., Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vietnam | |
| Plant parts | Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 8 | |
| Gene or Protein evidence | Flow cytometric analysis showed that AMR induced caspase-8 activation in 40.8-71% MCF-7, 28.5-43.2% MCF-7/TH and 4-32.8% MCF-10A cells at 1-8 microg/ml concentrations. | |
| Target pathways | NA | |
| IC50 | 3.8 μg/mL against MCF-7 6.8 μg/mL against MCF-7/TH 6.9 μg/mL against MCF-10A | |
| Potency | In situ cell death detection assay indicated that AMR caused 37.3-72.1% apoptotic cells in MCF-7, 32-48.7% in MCF-7/TH and 0-37.1% in MCF- 10A cells at 1-8 microg/ml concentrations. | |
| Cell line/ mice model | MCF-7, MCF-7/TH, MCF-10A | |
| Additional information | Our results suggest that AMR is a novel drug having potential for clinical development against human malignancies | |
| PubChem ID | 11503749 | |
| Additional PMIDs | 23475563 14503804 17028990 11933149 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:577579-1 | |
| Safety | NA |