| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-580 | |
| Phytochemical name or plant extracts | Amoora chittagonga extract | |
| PMID | 21584193 | |
| Literature evidence | For MCF-7 cancer cells, the chittagonga (Pet-Ether and CH(2)Cl(2)) and rohituka (Pet-Ether) extracts induced cytotoxicity, the chittagonga (EtoAC) and rohituka (MeOH) extracts did not induce cytotoxicity. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Petroleum ether, Dichloromethane extract, Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Amoora chittagonga | |
| Geographical availability | Assam, Bangladesh, East Himalaya, Myanmar, Thailand | |
| Plant parts | Stem | |
| Other cancers | Breast cancer, Pancreatic cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | Pet-Ether - ~42 μg/mL against MCF-7 CH2Cl2 - ~48 μg/mL against MCF7 | |
| Potency | For MCF-7 cancer cells, the chittagonga (Pet-Ether and CH(2)Cl(2)) and rohituka (Pet-Ether) extracts induced cytotoxicity; the chittagonga (EtoAC) and rohituka (MeOH) extracts did not induce cytotoxicity. | |
| Cell line/ mice model | MCF-7, HTB-126, Panc-1, Mia-Paca2, Capan1 | |
| Additional information | Treatment of Panc-1, Mia-Paca2, and Capan-1 cancer cell revealed that only the chittagonga CH2Cl2 extract showed significant cytotoxicity with IC50 values of ~39 μg/mL, 30 μg/mL, and 65 μg/mL, respectively. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:577019-1 | |
| Safety | The extracts were not cytotoxic to normal fibroblast Hs68 cells, which may be correlated to the specificity of Amoora extracts in targeting cancerous cells. |