| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1699 | |
| Phytochemical name or plant extracts | Alysicarpus vaginalis extract | |
| PMID | 31630563 | |
| Literature evidence | Additionally, AVEAF exerted anticancer effect on tumor-bearing rats and the tumor inhibition rate is 50%. Data of the study indicate that AVEAF exhibits In Vitro and In Vivo anticancer activities that associate with its ROS-mediated mitochondrial-mediated intrinsic pathway of apoptosis and necroptosis in MCF-7 cells and may serve as a potential against breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethyl acetate fraction | |
| Source of phytochemicals or plant Extracts | Alysicarpus vaginalis | |
| Geographical availability | Assam, India, Oman, Pakistan, Saudi Arabia, Yemen | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, Bcl-xL, PARP-1 | |
| Gene or Protein evidence | AVEAF increased the expression of pro-apoptotic protein Bax while decreasing anti-apoptotic proteins Bcl-2 and Bcl-xL expression which promoted the cleavage of caspase-9, PARP1, RIPK 1, and RIPK 3. | |
| Target pathways | AVEAF exhibits In Vitro and In Vivo anticancer activities that associate with its ROS-mediated mitochondrial-mediated intrinsic pathway of apoptosis and necroptosis in MCF-7 cells | |
| IC50 | NA | |
| Potency | AVEAF showed significant anticancer activity on administration to MNU induced cancer rats. It reduced tuomur progression, multiplicity and size, increased the latency period with better histological architecture. Therefore, our results indicate that AVEAF may be used as a natural chemomodulatory agent | |
| Cell line/ mice model | Sprague-Dawley rats, MCF-7 and MDA-MB-453 | |
| Additional information | AVEAF elevated intracellular ROS level in the MCF-7 cells which were reversed with N-acetycysteine (2 mM) pretreatment indicating that AVEAF induced mitochondrial-mediated apoptosis via augmentation of intracellular ROS. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:473530-1 | |
| Safety | NA |