| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-829 | |
| Phytochemical name or plant extracts | Alpinia galanga rhizhome extract | |
| PMID | 24935101 | |
| Literature evidence | BACKGROUND: We investigated the potential of galangal rhizomes to induce cytotoxic and apoptotic effects in the cultured human breast carcinoma cell line, (MCF-7) in compare with the non-malignant (MRC-5) cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Alpinia galanga | |
| Geographical availability | Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, Hainan, Jawa, Malaya, Myanmar, Philippines, Sumatera, Thailand, Vietnam | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 400.0 ± 11.7 and 170.0 ± 5.9 μg/ml after 48 and 72 h respectively against MCF-7 | |
| Potency | We concluded that the extract of Alpinia galanga exerts pro-apoptotic effects in a breast cancer-derived cell line and could be considered as a potential chemotherapeutic agent in breast cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | The results showed that the ethanolic extract of galangal rhizomes decreased cell viability in the malignant cells as a concentration- and time- dependent manner. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:795279-1 | |
| Safety | NA |