| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1062 | |
| Phytochemical name or plant extracts | Alpha-lipoic acid | |
| PMID | 20580704 | |
| Literature evidence | Alpha-lipoic acid, a naturally occurring reactive oxygen species scavenger, has been shown to possess anticancer activity, due to its ability to suppress proliferation and to induce apoptosis in different cancer cell lines. | |
| IUPAC name | 5-(dithiolan-3-yl)pentanoic acid | |
| Phytochemicals’ class or type of plant extracts | Organosulfur compound | |
| Source of phytochemicals or plant Extracts | Arabidopsis thaliana | |
| Geographical availability | Afghanistan, Albania, Algeria, Altay, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Canary Is., Cape Verde, Central European Rus, China North-Central, China South-Central, China Southeast, Corse, Cyprus, Czechoslovakia, Denmark, Djibouti, East Aegean Is., East European Russia, East Himalaya, Eritrea, Ethiopia, Finland, France, Germany, Great Britain, Greece, Hungary, Iran, Ireland, Italy, Japan, Kazakhstan, Kenya, Kirgizstan, Korea, Krasnoyarsk, Kriti, Krym, Lebanon-Syria, Libya, Madeira, Mongolia, Morocco, Nepal, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Pakistan, Palestine, Poland, Portugal, Romania, Rwanda, Sardegna, Saudi Arabia, Sicilia, Somalia, South European Russi, Spain, Sudan, Sweden, Switzerland, Tadzhikistan, Tanzania, Tibet, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Tuva, Uganda, Ukraine, Uzbekistan, West Himalaya, West Siberia, Xinjiang, Yugoslavia, Zaïre | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Cervical cancer, Neuroblastoma | |
| Target gene or protein | p27(kip1), Bax, Bcl-2 | |
| Gene or Protein evidence | We observed that alpha-lipoic acid is able to scavenge reactive oxygen species in MCF-7 cells and that the reduction of reactive oxygen species is followed by cell growth arrest in the G1 phase of the cell cycle, via the specific inhibition of Akt pathway and the up-regulation of the cyclin-dependent kinase inhibitor p27(kip1), and by apoptosis, via changes of the ratio of the apoptotic-related protein Bax/Bcl-2. | |
| Target pathways | PI3-K/Akt signalling pathway | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, SK-N-SH, Hela | |
| Additional information | Alpha-lipoic acid acts as a free radical scavenger and assists in repairing oxidative damage and regenerates endogenous antioxidants, including vitamins C and E and glutathione. This agent also promotes glutathione synthesis. In addition, alpha-lipoic acid exerts metal chelating capacities and functions as a cofactor in various mitochondrial enzyme complexes involved in the decarboxylation of alpha-keto acids. | |
| PubChem ID | 864 | |
| Additional PMIDs | 14608115 33322582 18164206 20580704 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:277970-1 | |
| Safety | NA |