| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-833 | |
| Phytochemical name or plant extracts | Alpha-Turmerone | |
| PMID | 20438793 | |
| Literature evidence | The findings revealed the potential use of CL crude extract (containing curcuminoids and volatile oil including turmerones) as chemopreventive agent. | |
| IUPAC name | 2-methyl-6-(4-methylcyclohexa-2,4-dien-1-yl)hept-2-en-4-one | |
| Phytochemicals’ class or type of plant extracts | Turmerone | |
| Source of phytochemicals or plant Extracts | Curcuma longa | |
| Geographical availability | India | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | α-turmerone induced apoptosis via activation of caspase-dependent pathway | |
| IC50 | 11.0 μg/ml against MDA-MB-231 41.8 μg/ml against MCF-7 | |
| Potency | The findings revealed the potential use of CL crude extract (containing curcuminoids and volatile oil including turmerones) as chemopreventive agent. | |
| Cell line/ mice model | HepG2, MCF-7, MDA-MB-231 | |
| Additional information | α-turmerone caused mitochondrial transmembrane depolarization in MDA-MB-231 cells and altered expression of Bcl-2 protein | |
| PubChem ID | 14632996 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:796451-1 | |
| Safety | NA |