| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-822 | |
| Phytochemical name or plant extracts | Alpha-Santalol | |
| PMID | 30061212 | |
| Literature evidence | BACKGROUND/AIM: Alpha-santalol, a terpenoid found in sandalwood oil has been shown to inhibit breast cancer cell growth in vitro by inducing apoptosis, but the mechanisms underlying the growth inhibitory effects of alpha-santalol are not fully understood. | |
| IUPAC name | (Z)-5-(2,3-dimethyl-3-tricyclo[2.2.1.02,6]heptanyl)-2-methylpent-2-en-1-ol | |
| Phytochemicals’ class or type of plant extracts | Terpenoid | |
| Source of phytochemicals or plant Extracts | Santalum album | |
| Geographical availability | Jawa, Lesser Sunda Is., Northern Territory, Philippines, Western Australia | |
| Plant parts | Sandalwood oil | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Wnt//β-catenin pathway | |
| IC50 | NA | |
| Potency | Alpha-santalol inhibited migration of breast cancer cells may be mediated, in part, by targeting Wnt//β-catenin pathway. β-catenin represents an important target of α-santalol's response for future pre-clinical studies. | |
| Cell line/ mice model | MDA-MB 231, MCF-7 | |
| Additional information | Exposure of MDA-MB 231 and MCF-7 cells to α-santalol resulted in a significant reduction in their migratory potential and wound healing ability. In addition, α-santalol affected the localization of β-catenin from cytosol to nucleus in MDA-MB 231 cells. | |
| PubChem ID | 5281531 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:780592-1 | |
| Safety | NA |