| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-540 | |
| Phytochemical name or plant extracts | Aloe vera extract | |
| PMID | 30600703 | |
| Literature evidence | The free radical scavenging activity of Aloe vera leaf extract is 67% to 89% (at 50 to 300 µg/ml). | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | NA | |
| Source of phytochemicals or plant Extracts | Aloe vera | |
| Geographical availability | Oman | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin D1, CYP 1A1, CYP 1A2, Bax, p21 | |
| Gene or Protein evidence | Interestingly, ACE did not have any significant cytotoxicity towards normal cells, thus placing it in the category of safe chemopreventive agent. Further, the effects were correlated with the downregulation of cyclin D1, CYP 1A1, CYP 1A2 and increased expression of bax and p21 in MCF-7 and HeLa cells. | |
| Target pathways | NA | |
| IC50 | 23 µg/mL against MCF-7 | |
| Potency | In conclusion, these results signify that Aloe vera may be an effective anti-neoplastic agent to inhibit cancer cell growth and increase the therapeutic efficacy of conventional drugs like cispolatin. | |
| Cell line/ mice model | MCF-7, Hela | |
| Additional information | Exposure of cells to ACE resulted in considerable loss of cell viability in a dose- and time-dependent fashion, which was found to be mediated by through the apoptotic pathway as evidenced by changes in the nuclear morphology and the distribution of cells in the different phases of the cell cycle. | |
| PubChem ID | NA | |
| Additional PMIDs | 33495932 9789122 25854386 30600703 27769229 34449259 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:530017-1 | |
| Safety | NA |