| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1067 | |
| Phytochemical name or plant extracts | Allyl Isothiocyanate | |
| PMID | 31404596 | |
| Literature evidence | Aberrant activity of sirtuins (SIRTs) has strong implications in the metastatic and oncogenic progression of TNBC. | |
| IUPAC name | 3-isothiocyanatoprop-1-ene | |
| Phytochemicals’ class or type of plant extracts | Isothiocyanate | |
| Source of phytochemicals or plant Extracts | Brassica nigra | |
| Geographical availability | Afghanistan, Albania, Algeria, Austria, Belgium, Bulgaria, China North-Central, Czechoslovakia, East Aegean Is., East Himalaya, Egypt, Ethiopia, France, Germany, Great Britain, Greece, Gulf States, Hungary, India, Iran, Iraq, Ireland, Italy, Kazakhstan, Kriti, Lebanon-Syria, Libya, Morocco, Netherlands, North Caucasus, Pakistan, Palestine, Poland, Qinghai, Romania, Sardegna, Sicilia, Sinai, Spain, Tibet, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Ukraine, West Himalaya, Xinjiang, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | TRPA1 | |
| Gene or Protein evidence | The chemical hyperalgesia produced by a TRPA1 agonist (allyl isothiocyanate, AITC) was also detected. | |
| Target pathways | AITC induced apoptosis in human breast cancer MCF-7 cells via AIF and Endo G signaling pathways, but in MDA-MB-231 cells apoptosis occurred via the GADD153 pathway. | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | ERK-modulated intrinsic signaling and G(2)/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells. | |
| PubChem ID | 5971 | |
| Additional PMIDs | 27080949 23008020 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:279422-1 | |
| Safety | NA |