| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-533 | |
| Phytochemical name or plant extracts | Allium hirtifolium extract | |
| PMID | 19002856 | |
| Literature evidence | Our results showed that components of A. hirtifolium might inhibit proliferation of tumor cell lines. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Chloroformic extract | |
| Source of phytochemicals or plant Extracts | Allium hirtifolium | |
| Geographical availability | Afghanistan, Iran, Iraq, Kazakhstan, Kirgizstan, Pakistan, Tadzhikistan, Turkey, Turkmenistan, Uzbekistan | |
| Plant parts | Bulb | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 24 μg/ml against MCF-7 | |
| Potency | A significant decrease in cell lines was observed in HeLa and MCF-7 as compared to L929 cell lines. DNA fragmentation analysis revealed a large number of apoptotic cells in treated HeLa and MCF-7 cell groups, but no effects in L929 cells. Therefore A. hirtifolium might be a candidate for tumor suppression. | |
| Cell line/ mice model | HeLa, MCF-7 , L929 | |
| Additional information | The inhibitory effect on tumor cell lines was 25 times stronger than that in normal cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:528159-1 | |
| Safety | Therefore, our results provided important insights into the use of A. hirtifolium as an additive to food or as a drug without any side effects. |