| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-531 | |
| Phytochemical name or plant extracts | Allium bakhtiaricum extracts | |
| PMID | 31164129 | |
| Literature evidence | Exposure of human breast cancer cells to different concentrations of the extracts at different incubation times did not induce apoptosis, autophagy or senescence. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Chloroform and ethyl acetate fractions | |
| Source of phytochemicals or plant Extracts | Allium bakhtiaricum | |
| Geographical availability | Iran | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Liver cancer, Colorectal cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | For 72h: Chloroformic fraction - 0.005 mg/ml against MDA-MB-231 Ethyl acetate fraction - 0.006 mg/ml against MDA-MB-231 | |
| Potency | the chloroform extract of A.bakhtiaricum potently suppressed the tumor growth in vitro and in vivo, a property which may be attributed to the presence of bioactive compounds in this plant with anti-breast cancer potential. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, 4T1 BALB/c mice, HepG2, HT-29 | |
| Additional information | The inhibitory effect of both fractions on the spreading of the 4 T1 breast cancer cells to a secondary site, i.e., lung, was also diminished in the treated groups, as recognized by a reduction in the number of metastatic nodules. In agreement with our previous data, the development of lung metastasis was lower in the chloroform-treated mice bearing 4 T1 cells than in the ethyl acetate-treated group. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:527667-1 | |
| Safety | NA |