| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-530 | |
| Phytochemical name or plant extracts | Allium autumnale extract | |
| PMID | 29370794 | |
| Literature evidence | CONCLUSION: Overall, our studies demonstrated the anti-cancer activities associated with Allium autumnale, revealing it's cytotoxic and anti-proliferative potential to be further utilized in in vivo studies. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Allium autumnale | |
| Geographical availability | Cyprus | |
| Plant parts | Bulb and Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Overall, in our present study, screening anti-cancer effects of AAB and AAS extracts revealed significant anti-proliferative and cytotoxic activities associated with the understudied endemic species Allium autumnale on model human breast cancer cell lines. Accordingly, active biological molecules obtained from these species could serve as potential anti-cancer agents, either as mono- or combination-therapies, depending on their cellular mechanisms of action on different cancer cell types. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | Allium autumnale bulb(AAB) extract (24, 48 and 72 h) exerts significant anti-proliferative effect on both MCF-7 and MDA-MB-231 cells where this effect for Allium autumnale stem(AAS) extract was observed only at high (5000 and 10,000 μg/mL) concentrations. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:527654-1 | |
| Safety | NA |