| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-529 | |
| Phytochemical name or plant extracts | Allium atroviolaceum extract (FAA) | |
| PMID | 29250124 | |
| Literature evidence | Overall, this study demonstrates the potential applications of Allium atroviolaceum extract as an anticancer drug for breast cancer treatment. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Allium atroviolaceum | |
| Geographical availability | Afghanistan, Bulgaria, Czechoslovakia, Greece, Hungary, Iran, Iraq, Italy, Krym, Lebanon-Syria, North Caucasus, Romania, Saudi Arabia, Tadzhikistan, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, Yugoslavia | |
| Plant parts | Flowers | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, Bcl-2, CDK-1, Caspase 3 | |
| Gene or Protein evidence | The underlying mechanism involved the stimulation of S and G2/M phase arrest in MCF-7 and S phase arrest in MDA-MB-231 associated with decreased level of Cdk1, in a p53-independent pathway. The apoptosis induction was related to downregulation of Bcl-2 and also likely to be caspase-dependent. The FAA extract was found to increase the activity of caspase-3 significantly only in MCF-7 cell line in IC25 value | |
| Target pathways | the FAA-induced apoptosis in both cells is likely to be caspase-dependent, Bcl-2-dependent, and p53-transcription-independent. | |
| IC50 | For 24h,48h,72h: 65.5 ± 9 μg/ml, 41 ± 0 μg/ml, 24.67 ± 3.5 μg/ml against MCF-7 77 ± 5.29 μg/ml, 67 ± 0 μg/ml, 51 ± 1.7 μg/ml against MDA-MB-231 | |
| Potency | Overall, this study demonstrates the potential applications of Allium atroviolaceum extract as an anticancer drug for breast cancer treatment. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | The IC50 concentration of TAM against MDA-MB-231 significantly reduced in the presence of FAA to 5.27 μg/ml, 6.8 μg/ml, and 0.73 μg/ml at 24, 48, and 72 h, respectively | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:527645-1 | |
| Safety | NA |