| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-534 | |
| Phytochemical name or plant extracts | Allicin | |
| PMID | 31404596 | |
| Literature evidence | Aberrant activity of sirtuins (SIRTs) has strong implications in the metastatic and oncogenic progression of TNBC. | |
| IUPAC name | 3-prop-2-enylsulfinylsulfanylprop-1-ene | |
| Phytochemicals’ class or type of plant extracts | Organosulfur | |
| Source of phytochemicals or plant Extracts | Allium sativum | |
| Geographical availability | Iran, Kazakhstan, Kirgizstan, Tadzhikistan, Turkmenistan, Uzbekistan | |
| Plant parts | Bulb | |
| Other cancers | Breast cancer, Cervical cancer, Lung cancer | |
| Target gene or protein | Caspase 3, Caspase 8, Caspase 9, NOXA, p21, Bak, Bcl-xL | |
| Gene or Protein evidence | In addition, allicin decreased cell viability and induced apoptosis by loss of ΔΨm, caspase-3, caspase-8, and caspase-9 activation, upregulation of NOXA, P21, and BAK, as well as downregulation of BCL-XL expression. | |
| Target pathways | NA | |
| IC50 | 0.20 μg/ml against MCF-7 | |
| Potency | Our results showed that allicin has antiproliferative, anticlonogenic, and senolytic effects. | |
| Cell line/ mice model | HeLa , MCF-7, L929, A549, HT29, HUVEC, HCC-70 | |
| Additional information | NA | |
| PubChem ID | 65036 | |
| Additional PMIDs | 28035949 19002856 11525603 28858299 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:528796-1 | |
| Safety | NA |