| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-206 | |
| Phytochemical name or plant extracts | Alisol A | |
| PMID | 31658635 | |
| Literature evidence | Taken together, our results demonstrated that alisol A could inhibit the proliferation and metastasis of MDA-MB-231 cells. | |
| IUPAC name | (5R,8S,9S,10S,11S,14R)-11-hydroxy-4,4,8,10,14-pentamethyl-17-[(2R,4S,5R)-4,5,6-trihydroxy-6-methylheptan-2-yl]-1,2,5,6,7,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-3-one | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Alisma plantago-aquatica | |
| Geographical availability | Afghanistan, Albania, Algeria, Altay, Amur, Assam, Austria, Baleares, Baltic States, Bangladesh, Belarus, Belgium, Bulgaria, Burundi, Buryatiya, Central European Rus, China North-Central, China South-Central, China Southeast, Chita, Corse, Czechoslovakia, Denmark, East Aegean Is., East European Russia, East Himalaya, Egypt, Eritrea, Ethiopia, Finland, France, Germany, Great Britain, Greece, Hungary, Inner Mongolia, Iran, Iraq, Ireland, Irkutsk, Italy, Japan, Kamchatka, Kazakhstan, Kenya, Khabarovsk, Kirgizstan, Korea, Krasnoyarsk, Kriti, Krym, Lebanon-Syria, Manchuria, Mongolia, Morocco, Myanmar, Nepal, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Pakistan, Palestine, Poland, Portugal, Primorye, Qinghai, Romania, Rwanda, Sakhalin, Sardegna, Sicilia, South European Russi, Spain, Sudan, Sweden, Switzerland, Tadzhikistan, Tanzania, Thailand, Transcaucasus, Turkey, Turkey-in-Europe, Tuva, Uganda, Ukraine, Uzbekistan, Vietnam, West Himalaya, West Siberia, Xinjiang, Yakutskiya, Yugoslavia, Zaïre | |
| Plant parts | Tuber | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin D1, MMP2, MMP9 | |
| Gene or Protein evidence | The expression level of cell cycle regulatory proteins cyclin D1 was significantly down regulated. Furthermore, alisol A significantly suppressed the migration and invasion of MDA-MB-231 cells by inhibiting the expression levels of MMP-2 and MMP-9. | |
| Target pathways | NF-κB and PI3K/Akt/mTOR pathway | |
| IC50 | NA | |
| Potency | Taken together, our results demonstrated that alisol A could inhibit the proliferation and metastasis of MDA-MB-231 cells. It could be a promising agent for breast cancer therapy. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Interestingly, autophagy inhibitor 3-MA significantly reversed the cytotoxic effects induced by alisol A. Meanwhile, alisol A-induced autophagy was significantly inhibited by 3-MA in MDA-MB-231 cells. Cell cycle analysis revealed that alisol A arrested the cell cycle at G0/G1 phase. | |
| PubChem ID | 15558616 | |
| Additional PMIDs | 24915879 24893804 31658635 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30019518-2 | |
| Safety | NA |