| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1319 | |
| Phytochemical name or plant extracts | Alisma canaliculatum extract | |
| PMID | 30177620 | |
| Literature evidence | Our results suggest that ACE has potential as a herbal supplement for the inhibition of breast cancer metastasis. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Alisma canaliculatum | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Japan, Korea, Kuril Is., Nansei-shoto, Taiwan | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | CXCR3, CXCL10, IKK-NF-kappaB | |
| Gene or Protein evidence | These results suggest that ACE abrogates TNFα-induced migration of MDA-MB-231 breast cancer cells through down-regulation of IKK-NF-kappaB-dependent CXCR3 and CXCL10 expression. | |
| Target pathways | ACE prevents TNFα-induced Migration of MDA-MB-231 metastatic breast cancer cells and inhibits TNFα-induced CXCR3 and CXCL10 expression through inhibition of the I?B kinase (IKK)-mediated NF-kappaB pathway. | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | ACE inhibits TNFα-induced phosphorylation of inhibitor of ?B (I?B) kinase (IKK), I?B and p65/RelA, leading to the suppression of nuclear translocation of p65/RelA nuclear factor kappa-B (NF-kappaB). Also, ACE inhibited NF-kappaB-dependent CXCR3 and CXCL10 promoter activities. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:327944-2 | |
| Safety | NA |