| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1368 | |
| Phytochemical name or plant extracts | Ajwa Dates Pulp Extract | |
| PMID | 33990623 | |
| Literature evidence | Phytochemicals from Ajwa dates pulp extract induce apoptosis in human triple-negative breast cancer by inhibiting AKT/mTOR pathway and modulating Bcl-2 family proteins. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract, Methanolic extract | |
| Source of phytochemicals or plant Extracts | Phoenix dactylifera | |
| Geographical availability | Gulf States, Iran, Iraq, Oman, Pakistan, Saudi Arabia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, Bax, Bcl-2, Fas, FasL, Caspase 3 | |
| Gene or Protein evidence | ADPE upregulated the p53, Bax and cleaved caspase-3, thereby leading to the downregulation of Bcl-2 and AKT/mTOR pathway. Decreased the mitochondrial membrane potential (MMP). Quantitative real time PCR (qRT-PCR) analysis showed up-regulation of p53, Bax, Fas, and FasL and down-regulation of Bcl-2. | |
| Target pathways | AKT/mTOR pathway Activates both intrinsic and extrinsic pathways | |
| IC50 | At 24h, 48h: 7.45 mg/mL, 16.67 mg/mL against MDA-MB-231 respectively | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | Cell cycle analysis demonstrated that ADPE induced cell arrest in S and G2/M checkpoints. | |
| PubChem ID | NA | |
| Additional PMIDs | 27441372 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:668912-1 | |
| Safety | ADPE did not show any significant toxicity on normal human peripheral blood mononuclear cells which suggests its safe application to biological systems under study. |