| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-851 | |
| Phytochemical name or plant extracts | Ailanthone | |
| PMID | 29552229 | |
| Literature evidence | The present study revealed the presence of ailanthone-mediated antitumor effects, indicating that ailanthone may be a novel phytomedicine with potential use in breast cancer therapy. | |
| IUPAC name | (1S,4R,5R,7S,11R,13S,17S,18S,19R)-4,5,17-trihydroxy-14,18-dimethyl-6-methylidene-3,10-dioxapentacyclo[9.8.0.01,7.04,19.013,18]nonadec-14-ene-9,16-dione | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Ailanthus altissima | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Inner Mongolia, Manchuria, Taiwan, Tibet, Xinjiang | |
| Plant parts | Bark | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2 | |
| Gene or Protein evidence | Western blot analysis was used to detect levels of Bax and Bcl-2 protein expression, it was demonstrated that following treatment of MCF-7 cells with 0.5, 1.0, 2.0, 4.0 or 8.0 µg/ml ailanthone for 48 h, Bax expression increased, whereas that of Bcl-2 decreased markedly. | |
| Target pathways | PI3K/AKT pathway | |
| IC50 | NA | |
| Potency | The present study revealed the presence of ailanthone-mediated antitumor effects, indicating that ailanthone may be a novel phytomedicine with potential use in breast cancer therapy. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Flow cytometry assay demonstrated that ailanthone induced apoptosis and G0/G1 cell cycle arrest in MCF-7 cells. Western blotting and RT-PCR assays demonstrated that upregulation of pro-apoptotic caspase-3 and Bcl-associated X, and downregulation of anti-apoptotic apoptosis regulator B-cell lymphoma-2 in MCF-7 cells may be associated with the induction of apoptosis and inhibition of proliferation. | |
| PubChem ID | 72965 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:813521-1 | |
| Safety | NA |