| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-582 | |
| Phytochemical name or plant extracts | Aglaiabbreviatin F (AA-6) | |
| PMID | 29050217 | |
| Literature evidence | After 48 h treatment, AA-5 (1) and AA-6 (2) significantly increased mitochondrial-mediated apoptosis by enhancing reactive oxygen species (ROS) with depressed mitochondrial membrane potential and caspase-9 activities. | |
| IUPAC name | [(3R,5R,8R,9R,10R,13R,14R,17S)-17-[(2S)-6-hydroperoxy-2-hydroxy-6-methylheptan-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Aglaia abbreviata | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, New Caledonia, New Guinea, Philippines, Queensland, Samoa, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vanuatu, Vietnam, Western Australia | |
| Plant parts | Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 9, P-gp | |
| Gene or Protein evidence | After 48 h treatment, AA-5 (1) and AA-6 (2) significantly increased mitochondrial-mediated apoptosis by enhancing reactive oxygen species (ROS) with depressed mitochondrial membrane potential and caspase-9 activities. Moreover, computational modeling studies showed that AA-6 (2) might bind to the modulator site on P-gp and act as an inhibitor, not a substrate of P-gp. | |
| Target pathways | Akt pathway | |
| IC50 | 12.46 µM against MCF-7 6.1 µM against MCF-7/ADM | |
| Potency | Therefore, AA-5 (1) and AA-6 (2) may be effective anti-tumor and reversal agents for the further development of therapeutics against MDR breast cancer. | |
| Cell line/ mice model | MCF-7, MCF-7/ADM | |
| Additional information | Importantly, AA-6 (2) were more effective than that of adriamycin (IC50 = 57.3 µM) and vincristine (IC50 = 7.5 µM) in MCF-7/ADM cells. | |
| PubChem ID | 50908450 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:577065-1 | |
| Safety | NA |