| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-581 | |
| Phytochemical name or plant extracts | Aglaiabbreviatin E (AA-5) | |
| PMID | 29050217 | |
| Literature evidence | After 48 h treatment, AA-5 (1) and AA-6 (2) significantly increased mitochondrial-mediated apoptosis by enhancing reactive oxygen species (ROS) with depressed mitochondrial membrane potential and caspase-9 activities. | |
| IUPAC name | (5R,8R,9R,10R,13R,14R,17S)-17-[(4E)-6-hydroxy-6-methylhepta-1,4-dien-2-yl]-4,4,8,10,14-pentamethyl-1,2,5,6,7,9,11,12,13,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Aglaia abbreviata | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, New Caledonia, New Guinea, Philippines, Queensland, Samoa, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vanuatu, Vietnam, Western Australia | |
| Plant parts | Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 9 | |
| Gene or Protein evidence | After 48 h treatment, AA-5 (1) and AA-6 (2) significantly increased mitochondrial-mediated apoptosis by enhancing reactive oxygen species (ROS) with depressed mitochondrial membrane potential and caspase-9 activities. | |
| Target pathways | Akt pathway | |
| IC50 | 14.80 µM against MCF-7 10.22 µM against MCF-7/ADM | |
| Potency | Therefore, AA-5 (1) and AA-6 (2) may be effective anti-tumor and reversal agents for the further development of therapeutics against MDR breast cancer. | |
| Cell line/ mice model | MCF-7, MCF-7/ADM | |
| Additional information | Therefore, AA-5 (1) and AA-6 (2) may be effective anti-tumor and reversal agents for the further development of therapeutics against MDR breast cancer. | |
| PubChem ID | 50908449 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:577065-1 | |
| Safety | NA |