| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-790 | |
| Phytochemical name or plant extracts | Aegle marmelos extract | |
| PMID | 14719119 | |
| Literature evidence | In this study we determined the activity of extracts from Bangladeshi medicinal plants (Emblica officinalis, Aegle marmelos, Vernonia anthelmintica, Oroxylum indicum, Argemone mexicana) on human breast tumor cell lines. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic fruit pulp extract | |
| Source of phytochemicals or plant Extracts | Aegle marmelos | |
| Geographical availability | Assam, Bangladesh, India, Nepal, Pakistan, West Himalaya | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Aegle marmelos treatment showed significantly reduced mammary tumor volume (P < 0.05), along with significant reduction (P < 0.0001) in the different serum biomarkers such as TNF-α level, serum malondialdehyde (MDA) level and glucose levels. | |
| Cell line/ mice model | MCF-7, MDA-MB-231/ Female Charles Foster strain rats | |
| Additional information | After the development of breast tumors (about 0.5 cm), the rats were treated with Aegle marmelos ethanolic fruit pulp extract (200 mg/kg b.w./day) orally for 5 weeks and then volume of tumor was measured. Aegle marmelos treatment showed significantly reduced mammary tumor volume (P < 0.05), along with significant reduction (P < 0.0001) in the different serum biomarkers such as TNF-α level, serum malondialdehyde (MDA) level and glucose levels. | |
| PubChem ID | NA | |
| Additional PMIDs | 12809360 16119004 33093498 27765350 24591736 23434131 26729368 26749840 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:770819-1 | |
| Safety | NA |