| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-879 | |
| Phytochemical name or plant extracts | Actinidia chinensis extract | |
| PMID | 34852177 | |
| Literature evidence | Thus, further studies are warranted to test the possibility that AcRoots may be used as a promising anticancer agent for breast cancer treatment. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Actinidia chinensis | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Taiwan | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, E-cadherin, Cyclin D1, Survivin, Bcl-2, N-cadherin, Snail | |
| Gene or Protein evidence | Moreover, ac roots decreased the expression of cyclin D1, survivin, Bcl-2, N-cadherin, and Snail and increased the expression of Bax and E-cadherin in MDA-MB-231 and MDA-MB-453 cells. | |
| Target pathways | AKT/GSK-3b pathway | |
| IC50 | NA | |
| Potency | Thus, further studies are warranted to test the possibility that AcRoots may be used as a promising anticancer agent for breast cancer treatment. | |
| Cell line/ mice model | MDA-MB-231 and MDA-MB-453 | |
| Additional information | AcRoots inhibited the AKT/GSK-3b pathway by decreasing the levels of phosphorylated AKT, phosphorylated GSK-3b and b-catenin. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:828396-1 | |
| Safety | NA |