| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-380 | |
| Phytochemical name or plant extracts | Acteoside | |
| PMID | 16198557 | |
| Literature evidence | Our study suggests that the nature is rich in selective ERalpha and ERbeta ligands, the discovery of which may lead to the development of novel neutraceutical agents. | |
| IUPAC name | [(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
| Phytochemicals’ class or type of plant extracts | Glycoside | |
| Source of phytochemicals or plant Extracts | Anisomeles indica | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, China South-Central, China Southeast, Christmas I., East Himalaya, India, Jawa, Laccadive Is., Laos, Lesser Sunda Is., Malaya, Maldives, Maluku, Myanmar, Nansei-shoto, Nepal, New Guinea, Nicobar Is., Pakistan, Philippines, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Tibet, Vietnam, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Acteoside and martynoside antagonized both ERalpha and ERbeta (p<0.001), whereas they reversed the effect of E(2) mainly via ERalpha (p<0.001). | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Acteoside was an antiestrogen in breast cancer cells and osteoblasts, without any effect on endometrial cells. | |
| PubChem ID | 5281800 | |
| Additional PMIDs | 31526250 25509294 22634262 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:444831-1 | |
| Safety | NA |