| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1700 | |
| Phytochemical name or plant extracts | Acridocarpus orientalis extract | |
| PMID | 31684146 | |
| Literature evidence | Thus, different parts of A. orientalis revealed variable potential to induce cell death in cancer cells via apoptotic and non-apoptotic pathways, making A. orientalis a valuable plant for the exploration of anticancer bioactive reagents, some of which may be protective for normal cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract (dichloromethane fraction) | |
| Source of phytochemicals or plant Extracts | Acridocarpus orientalis | |
| Geographical availability | Gulf States, Iran, Oman, Saudi Arabia, Somalia, Yemen | |
| Plant parts | Leaves and stem | |
| Other cancers | Breast cancer, Colorectal cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | AOD (L) can induce both apoptosis and another cell death pathway, necroptosis, in HeLa cells. | |
| IC50 | 98.5 µg/mLagainst MCF-7 167.4 µg/mL against MCF-10A 201.5 µg/mL against MDA-MB-231 | |
| Potency | Overall, our results reveal that A. orientalis has significant anticancer potential against human cancer cell lines and most of the activity resides primarily within its leaves. Furthermore, it has the potential to induce apoptosis, necroptosis, and autophagy in human cervical cancer, while probably only autophagy in breast cancer cells. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, MCF-10A, HeLa | |
| Additional information | A. orientalis extracts/fractions contain substantial amounts of flavonoids and phenolic compounds with effective antioxidant, lipid peroxidation, and cytotoxic activities against colorectal and liver cancer cells, such as HT29, HCT116, and HepG2. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:555356-1 | |
| Safety | NA |