| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1037 | |
| Phytochemical name or plant extracts | Achyrobichalcone | |
| PMID | 32710804 | |
| Literature evidence | Achyrocline satureioides compounds, achyrobichalcone and 3-O-methylquercetin, induce mitochondrial dysfunction and apoptosis in human breast cancer cell lines. | |
| IUPAC name | (2E)-1-(2-hydroxy-4-{3-hydroxy-4-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-5-methoxyphenoxy}-6-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one | |
| Phytochemicals’ class or type of plant extracts | Chalcone | |
| Source of phytochemicals or plant Extracts | Achyrocline satureioides | |
| Geographical availability | Argentina Northeast, Argentina Northwest, Bolivia, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Colombia, Ecuador, Paraguay, Peru, Uruguay | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 9, Caspase 3, Caspase 7 | |
| Gene or Protein evidence | Cell death by both compounds was associated with caspase-9 and caspase-3/7 activation. | |
| Target pathways | Mitochondrial-dependent pathway | |
| IC50 | 8.43 μM against MDA-MB-231 | |
| Potency | Interestingly, ACB had increased cytotoxicity compared to 3OMQ in MDA-MB-231 cells as indicated by their IC50 values of 8.43 and 28.34 μM after 48 hr of treatment, respectively. | |
| Cell line/ mice model | MDA-MB-231 and MCF-12A | |
| Additional information | Moreover, after 8-hr (50 μM) treatment with either molecule, MDA-MB-231 cells showed a significant reduction in basal mitochondrial respiration. It seems that both molecules exert a similar effect over mitochondrial respiration and function, however, ACB showed a faster action in acute high-dose treatments. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:174407-1 | |
| Safety | NA |