| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1544 | |
| Phytochemical name or plant extracts | Achyranthes bidentata Blume extract | |
| PMID | 32772566 | |
| Literature evidence | According to the in vitro experiments, the isolated compounds showed significant inhibitory activities on MCF-7 cells as well as anti-inflammatory activities by attenuating the production of NO and TNF-α in LPS-induced macrophage cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid and phytosterones content | |
| Source of phytochemicals or plant Extracts | Achyranthes bidentata Blume | |
| Geographical availability | Assam, Bangladesh, Borneo, Cambodia, Caroline Is., China North-Central, China South-Central, China Southeast, East Himalaya, Hainan, India, Japan, Jawa, Korea, Laos, Lesser Sunda Is., Malaya, Maluku, Marianas, Myanmar, Nansei-shoto, Nepal, New Guinea, Nicobar Is., Ogasawara-shoto, Pakistan, Philippines, Solomon Is., Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Tibet, Vietnam, West Himalaya | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | TNF-α | |
| Gene or Protein evidence | According to the in vitro experiments, the isolated compounds showed significant inhibitory activities on MCF-7 cells as well as anti-inflammatory activities by attenuating the production of NO and TNF-α in LPS-induced macrophage cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In conclusion, this study successfully predicted and confirmed the positive impact of triterpenoids and phytosterones on breast cancer, which provided a foundation for further in vivo studies. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:58678-1 | |
| Safety | NA |