| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-426 | |
| Phytochemical name or plant extracts | Acacia etbaica extract | |
| PMID | 32700973 | |
| Literature evidence | Among these compounds are three new simple phenolics: Resacetophenone-6-methyl [1], Resorcinol [2], Resorcinol-O- β -Glucoside [3], phenolic ester, and other four known compounds: Methylparaben [4], two chromones, Noreugenin [5], Eugenin [6], and one cyclitol: pinitol [7]. Compounds [1-3] isolated and identified for the first time from natural origin. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | n-Butanol extract | |
| Source of phytochemicals or plant Extracts | Acacia etbaica | |
| Geographical availability | Djibouti, Egypt, Eritrea, Ethiopia, Kenya, Oman, Saudi Arabia, Somalia, Sudan, Tanzania, Uganda, Yemen | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Liver cancer, Colorectal cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 9.42 ± 0.8 μg/mL against MCF-7 | |
| Potency | In contrast, the n-butanol extract showed extreme cytotoxic activity against Mammary gland breast cancer (MCF-7), and strong activity against Hepatocellular carcinoma (HEPG-2), and Colorectal carcinoma (HCT-116) cell lines. | |
| Cell line/ mice model | MCF-7, HEPG-2, HCT-116 | |
| Additional information | As for the activity against mammary gland breast MCF-7, the very strong cytotoxic activity was displayed by an IC50 value of 9.42 ± 0.8. while, the strong inhibitory activity, ranging from 11.0–19.7, were shown against hepatocellular carcinoma (liver) HepG2, which was displayed by IC50 value of 14.83 ± 1.3 and colon cancer HCT-116 which was displayed by IC50 value of 16.83 ± 1.4 | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:470281-1 | |
| Safety | NA |