| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-793 | |
| Phytochemical name or plant extracts | Acacia catechu extract (ACME) | |
| PMID | 24695415 | |
| Literature evidence | Flow cytometric analysis and morphological studies confirmed that ACME is able to induce apoptosis in MCF-7 cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Acacia catechu | |
| Geographical availability | Assam, Bangladesh, China South-Central, East Himalaya, India, Myanmar, Nepal, Pakistan, Thailand, West Himalaya | |
| Plant parts | heartwood extract | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2 | |
| Gene or Protein evidence | In conclusion, the present report demonstrates that 70% methanolic extract of Acacia catechu exhibits an anti-proliferative activity by induction of apoptosis through upregulation of Bax/Bcl-2 ratio i.e., through intrinsic pathway. | |
| Target pathways | Intrinsic pathway | |
| IC50 | 288.85 ± 25.79 μg/ml against MCF-7 | |
| Potency | Immunoblot results suggested the pathway of apoptosis induction by increasing Bax/Bcl-2 ratio which results in the activation of caspase-cascade and ultimately leads to the cleavage of Poly adeno ribose polymerase (PARP) | |
| Cell line/ mice model | MCF-7 | |
| Additional information | It is found that Bax expression was significantly elevated in ACME treated MCF-7 cells while Bcl-2 expression remains unchanged which ultimately results in an increase in the Bax/Bcl-2 ratio and activation of the caspase cascade. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:469951-1 | |
| Safety | NA |