| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-120 | |
| Phytochemical name or plant extracts | Acacetin | |
| PMID | 19666078 | |
| Literature evidence | Cotreatment of the CYP1 family inhibitor acacetin reversed the antiproliferative activity noticed for the two flavones in MDA-MB-468 cells to 13 and 14 microM respectively. | |
| IUPAC name | 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Calea urticifolia | |
| Geographical availability | Belize, Costa Rica, El Salvador, Guatemala, Honduras, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | STAT-3, CYP1A1, CYP1B1 | |
| Gene or Protein evidence | Sudachitin, chrysoeriol, and acacetin also exerted significantly cytotoxicity, clearly suppressed constitutive STAT3 activation, and induced apoptosis, although hesperetin did not show any significant effect in DU145 cells. The intracellular CYP1-mediated bioconversion of the flavone was reduced in the presence of the CYP1A1 and CYP1B1-selective inhibitors α-napthoflavone and acacetin. | |
| Target pathways | PI3K/AKT/mTOR/p70S6K/ULK signaling pathway | |
| IC50 | NA | |
| Potency | These findings indicate that both acacetin and pinostrobin may serve as potential therapeutic options to target breast tumor cell migration during late-stage tumor progression. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, T47D | |
| Additional information | Naturally occurring flavonoids, such as acacetin and pinostrobin, disrupt a wide range of processes during tumor progression, such as cell proliferation, apoptosis, and angiogenesis. Two of the flavones, 3',4',7-trimethoxyflavone and acacetin, showed only low anti-P-gp activity, with the remainder displaying no suppressive effects against P-gp. | |
| PubChem ID | 5280442 | |
| Additional PMIDs | 28539711 22438130 9492340 15202555 32493139 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:187796-1 | |
| Safety | NA |