| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1460 | |
| Phytochemical name or plant extracts | 9 - hydroxycalabaxanthone | |
| PMID | 30978023 | |
| Literature evidence | Among the compounds tested for their cytotoxicity, 26 showed significant cytotoxic effects against five human cancer cell lines, including MCF-7, HT-29, KB, Hep G2, and HeLa S3, with IC50 values in the range of 1.6-3.4 μM, while 10 and 11 were cytotoxic against the MCF-7, HeLa S3, and KB cell lines, with IC50 values of 4.3-9.0 μM. | |
| IUPAC name | 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)pyrano[3,2-b]xanthen-6-one | |
| Phytochemicals’ class or type of plant extracts | Xanthone | |
| Source of phytochemicals or plant Extracts | Garcinia tetrandra | |
| Geographical availability | Philippines, Sulawesi | |
| Plant parts | Stem | |
| Other cancers | Breast cancer, Colon cancer, Squamous cell cancer, Liver cancer, Cervical cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 1.9 ± 0.1 µM against MCF-7 | |
| Potency | Previous reports have revealed that prenylated and geranylated xanthones isolated from plants, especially in the genus Garcinia, possess potent cytotoxic properties against several cancer cell lines | |
| Cell line/ mice model | MCF-7, HT-29, KB, Hep G2, and HeLa S3 | |
| Additional information | Shows significant cytotoxic effects against five human cancer cell lines, including MCF-7, HT-29, KB, Hep G2, and HeLa S3 | |
| PubChem ID | 5495929 | |
| Additional PMIDs | 32691623 19839614 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:428268-1 | |
| Safety | NA |