| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2063 | |
| Phytochemical name or plant extracts | 7-hydroxy, 5-methoxy, methyl cinnamate (1) | |
| PMID | 33578916 | |
| Literature evidence | Accordingly, it was subjected to chromatographic separation, which resulted in the isolation of a new natural product; 7-hydroxy, 5-methoxy, methyl cinnamate (1), together with four known compounds. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Phenolic acid | |
| Source of phytochemicals or plant Extracts | Phyllostachys heterocycla var. pubescens | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Taiwan | |
| Plant parts | Bamboo shoot skin | |
| Other cancers | Breast cancer, Liver cancer | |
| Target gene or protein | EGFR tyrosine kinase | |
| Gene or Protein evidence | Finally, compound 1 was validated as EGFR tyrosine kinase inhibitor in both enzymatic levels (IC50 = 98.65 nM compared to Erlotinib (IC50 = 78.65 nM). | |
| Target pathways | NA | |
| IC50 | 10.65 µM against MCF-7 | |
| Potency | It induced apoptotic cell death in HepG2 with total apoptotic cell death of 58.6% (12.44-fold) compared to 4.71% in control by arresting cell cycle progression at the G1 phase. | |
| Cell line/ mice model | MCF-7, HepG2 | |
| Additional information | Finally, in silico studies of compound 1 through the molecular docking indicated its high binding affinity towards EGFR protein and the ADME pharmacokinetics indicated it as a drug-like. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:416011-1 | |
| Safety | NA |