| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-399 | |
| Phytochemical name or plant extracts | 7β-acetoxy-20-hydroxy-19,20-epoxyroyleanone (compound 1) | |
| PMID | 31254584 | |
| Literature evidence | Partial rescue of survival obtained with n-acetylcysteine (NAC) when coadminstered with compound 1 further supported a contribution of ROS mediated mechanisms to the growth-arrest and proapoptotic activity of compound 1 in both BCa cell lines. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Salvia corrugata | |
| Geographical availability | Colombia, Ecuador, Peru | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | ERK1/2 kinase | |
| Gene or Protein evidence | Furthermore, we also detected a potent activation of the ERK1/2 kinase, which suggested the induction of reactive oxygen species (ROS). | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our findings show that compound 1 has a cytotoxic activity against both human normal and cancer cell lines derived from breast epithelia, which is mediated by ROS generation and mitochondrial damage. | |
| Cell line/ mice model | MCF-10A, SKBR-3, BT-474 | |
| Additional information | Compound 1 inhibited cell survival of all breast cell lines. In particular, compound 1 promoted cell cycle arrest in the G0/G1 phase and apoptosis along with impairment of the mitochondrial function, which was reflected in a gross alteration of the mitochondrial network structure. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:456028-1 | |
| Safety | NA |