| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1469 | |
| Phytochemical name or plant extracts | 7,14- O-(1-methylethylidene)oridonin | |
| PMID | 28869908 | |
| Literature evidence | Four isolates exhibited significant inhibitory ability against all cell lines, with IC50 values ranging from 0.5 to 6.5 μM, They also strongly inhibited NO production in LPS-stimulated RAW264.7 cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Isodon rubescens | |
| Geographical availability | China North-Central, China South-Central, China Southeast | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Leukemia, Lung cancer, Liver cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 3.9 ± 0.16 µM against MCF-7 | |
| Potency | As a result, compounds 2, 5, 13, 14 and 28 exhibited potent active effects with IC50 values of 1.2, 1.3, 1.3, 0.8 and 1.1 mM, respectively. Compound 28 is 7,14- O-(1-methylethylidene)oridonin | |
| Cell line/ mice model | HL-60, SMMC-7721, A-549, MCF-7, RAW264.7 SW484 | |
| Additional information | Exhibits significant inhibitory ability against all cell lines and also strongly inhibits NO production in LPS-stimulated RAW264.7 cells | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:915158-1 | |
| Safety | NA |