| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-774 | |
| Phytochemical name or plant extracts | 7, 3', 5'-trihydroxyflavanone | |
| PMID | 20441573 | |
| Literature evidence | CONCLUSIONS: Our results provide evidence that plant-derived 3HFD was able to induce the apoptotic cell death of MCF-7 cells by increasing Bax expression level and makes 3HFD a promising agent for chemotherapy, which merits further study. | |
| IUPAC name | (2S)-2-(3,5-dihydroxyphenyl)-7-hydroxy-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Hydnophytum formicarum | |
| Geographical availability | Andaman Is., Borneo, Cambodia, Jawa, Malaya, Maluku, Myanmar, New Guinea, Philippines, Sulawesi, Sumatera, Thailand, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Bax | |
| Gene or Protein evidence | Our study demonstrates that 3HFD induced apoptosis in MCF-7 cells. Apoptosis was caused by decreasing the level of the anti-apoptotic protein Bcl-2 and up-regulation of pro-apoptotic Bax. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our results provide evidence that plant-derived 3HFD was able to induce the apoptotic cell death of MCF-7 cells by increasing Bax expression level and makes 3HFD a promising agent for chemotherapy, which merits further study. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | 12084411 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:753446-1 | |
| Safety | NA |