| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1212 | |
| Phytochemical name or plant extracts | 6-shogaol | |
| PMID | 23417847 | |
| Literature evidence | In conclusion, the present study demonstrates for the first time that 6-shogaol and pterostilbene can inhibit invadopodium formation and MMP activity in highly invasive breast cancer cells. | |
| IUPAC name | (E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one | |
| Phytochemicals’ class or type of plant extracts | Monomethoxybenzene | |
| Source of phytochemicals or plant Extracts | Zingiber officinale | |
| Geographical availability | Andaman Is., Bangladesh, Borneo, Cambodia, Caroline Is., China Southeast, Comoros, Costa Rica, Cuba, Dominican Republic, Gulf of Guinea Is., Hainan, Haiti, Honduras, Leeward Is., Lesser Sunda Is., Madagascar, Malaya, Mauritius, Mexico Southwest, Myanmar, New Guinea, Nicobar Is., Philippines, Puerto Rico, Queensland, Rodrigues, Réunion, Solomon Is., Sri Lanka, Taiwan, Thailand, Trinidad-Tobago, Vanuatu, Vietnam, Windward Is. | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Lung cancer | |
| Target gene or protein | MT1-MMP, c-Src kinase, cortactin, JNK, NF-κB, STAT-3, CCL2, Aromatase | |
| Gene or Protein evidence | Further investigation into the underlying molecular mechanisms revealed that the levels of key modulators of invadopodium maturation, including c-Src kinase, cortactin, and membrane type 1-matrix metalloproteinase (MT1-MMP) decreased when cells were treated with 6-shogaol or pterostilbene. In addition, 6-shogaol was found to inhibit JNK activation with no resulting reduction in activator protein-1 transcriptional activity. The NF-κB transcriptional activity was decreased by 6-shogaol, an effect mediated by inhibition of IκB phosphorylation and degradation that subsequently led to suppression of NF-κB p65 phosphorylation and nuclear translocation. A549 and MDA-MB-231 cells enhance CCL2 expression by increasing the phosphorylation of signal transducer and activator of transcription 3 (STAT3), and the activation of STAT3 induced by A549 and MDA-MB-231 is completely inhibited by 6-shogaol. 6-Shogaol also decreases the metastasis of lung and breast cancers in mice. 6-Shogaol exerts significant anticancer effects on lung and breast cells in vitro and in vivo by targeting the CCL2 secreted by TADCs. For the current investigation, 36 phytochemical antioxidants have been assessed computationally to discover the highly effective compounds against BC protein, aromatase. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In conclusion, the present study demonstrates for the first time that 6-shogaol and pterostilbene can inhibit invadopodium formation and MMP activity in highly invasive breast cancer cells. | |
| Cell line/ mice model | MDA-MB-231, A549 | |
| Additional information | NA | |
| PubChem ID | 5281794 | |
| Additional PMIDs | 31690139 27609747 31089409 23435947 25621970 29464796 23417847 20718733 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:798372-1 | |
| Safety | NA |