| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1039 | |
| Phytochemical name or plant extracts | 6-prenylnaringenin (6-PN) | |
| PMID | 25044854 | |
| Literature evidence | METHODS AND RESULTS: ABCG2-inhibitory activity of xanthohumol (XN), isoxanthohumol (IX), 6-prenylnaringenin (6-PN), 8-prenylnaringenin (8-PN), and 6,8-diprenylnarigenin (6,8-diPN) was evaluated using mitoxantrone accumulation and vesicular transport assays. | |
| IUPAC name | (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Humulus lupulus | |
| Geographical availability | Albania, Altay, Austria, Baltic States, Belarus, Belgium, Bulgaria, Buryatiya, Central European Rus, Chita, Corse, Czechoslovakia, Denmark, East European Russia, Finland, France, Germany, Great Britain, Greece, Hungary, Iran, Irkutsk, Italy, Kazakhstan, Krasnoyarsk, Krym, Morocco, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Poland, Portugal, Romania, Sardegna, Sicilia, South European Russi, Spain, Sweden, Switzerland, Transcaucasus, Turkey, Turkey-in-Europe, Ukraine, West Siberia, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Prostate cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | 6-prenylnaringenin was stronger than cisplatin against breast cancer cell line T-47D. | |
| Cell line/ mice model | MDA-MB-231, T-47D, PC-3, HT-29, A-2780 | |
| Additional information | NA | |
| PubChem ID | 155094 | |
| Additional PMIDs | 30423918 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:303502-2 | |
| Safety | NA |