| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-845 | |
| Phytochemical name or plant extracts | 6-methoxy-2E,9E-humuladien-8-one | |
| PMID | 18972844 | |
| Literature evidence | Histone deacetylase (HDAC) inhibitors that inhibit proliferation and induce differentiation and/or apoptosis of tumor cells in culture and in animal models have been identified. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Sesequiterpenoid | |
| Source of phytochemicals or plant Extracts | Zingiber zerumbet | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, India, Laos, Malaya, Myanmar, Nicobar Is., Philippines, Taiwan, Thailand, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 1.45 μM against MDA-MB-231 | |
| Potency | Compound 1 exhibited growth inhibitory activity on six human tumor cell lines, and showed potential inhibitory activity in histone deacetylase (HDAC) enzyme assay (GI50 = 1.25 microM). | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Isolation of the n-hexane soluble fraction from Zingiber zerumbet yielded two major sesequiterpenoids, 6-methoxy-2E,9E-humuladien-8-one (1) and zerumbone (2). | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:798401-1 | |
| Safety | NA |