| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-844 | |
| Phytochemical name or plant extracts | 6-gingerol | |
| PMID | 33925065 | |
| Literature evidence | Thus, treatment with natural compounds has been considered a better approach as this minimizes side effects and has multiple targets. 6-Gingerol is an active polyphenol in ginger with various modalities, including anticancer activity, although its mechanism of action remains unknown. | |
| IUPAC name | (5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one | |
| Phytochemicals’ class or type of plant extracts | Polyphenol | |
| Source of phytochemicals or plant Extracts | Zingiber officinale | |
| Geographical availability | Assam, China South-Central, East Himalaya, India | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, Bax, Bcl-2, cyt-c | |
| Gene or Protein evidence | 6-Gingerol induced cellular and mitochondrial ROS that elevated DDR through ataxia-telangiectasia mutated and p53 activation. 6-Gingerol also induced G0/G1 cell cycle arrest and mitochondrial apoptosis by mediating the BAX/BCL-2 ratio and release of cytochrome c. | |
| Target pathways | EGFR/Src/STAT3 signaling | |
| IC50 | NA | |
| Potency | Therefore, 6-gingerol may be used as a candidate drug against hormone-dependent breast cancer cells. | |
| Cell line/ mice model | MDA-MB-231 and MCF-7 | |
| Additional information | EGFR/Src/STAT3 signaling was also determined to be responsible for p53 activation and that 6-gingerol induced p53-dependent intrinsic apoptosis in breast cancer cells. | |
| PubChem ID | 442793 | |
| Additional PMIDs | 28869564 31690139 33925065 27399668 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:798372-1 | |
| Safety | NA |