| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2004 | |
| Phytochemical name or plant extracts | 6-(4,6-dioxo-1,4,5,6-tetrahydropyrimidin-2-yl-amino)hexanoic acid trifluoroacetate | |
| PMID | 31148892 | |
| Literature evidence | CONCLUSION: Thus, from this study it can be concluded that, these screened natural compounds from E. crispa leaves may serve as potential inhibitors for HER2 and they might lead to development of new therapeutic agents against cancer and its associated complications. | |
| IUPAC name | 6-[(4,6-dioxo-1,3-diazinan-2-ylidene)amino]hexanoic acid;2,2,2-trifluoroacetic acid | |
| Phytochemicals’ class or type of plant extracts | NA | |
| Source of phytochemicals or plant Extracts | Euclea crispa | |
| Geographical availability | Angola, Botswana, Cape Provinces, Free State, KwaZulu-Natal, Lesotho, Malawi, Mozambique, Northern Provinces, Swaziland, Zambia, Zimbabwe | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Ovarian cancer | |
| Target gene or protein | Her2 | |
| Gene or Protein evidence | These screened compounds were strongly bound with hydrophobic region of HER2 protein as predicted. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The HER2 receptor is a novel and important therapeutic target in a variety of cancers including breast and ovarian cancer. Thus, from this study it can be concluded that, these screened natural compounds from E. crispa leaves may serve as potential inhibitors for HER2 and they might lead to development of new therapeutic agents against cancer and its associated complications. | |
| Cell line/ mice model | In-silico | |
| Additional information | NA | |
| PubChem ID | 135998927 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:50873080-1 | |
| Safety | NA |