| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-602 | |
| Phytochemical name or plant extracts | 6,7-di-O-acetylsinococuline (FK-3000) | |
| PMID | 25823424 | |
| Literature evidence | These studies demonstrate that FK-3000, isolated from S. delavayi Diels., is a promising, pathway-specific anticancer agent that exhibits low toxicity. | |
| IUPAC name | [(1S,9S,12S,13S)-12-acetyloxy-3-hydroxy-4,11-dimethoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,10-tetraen-13-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Stephania delavayi | |
| Geographical availability | China South-Central, Myanmar | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Prostate cancer, Colon cancer | |
| Target gene or protein | NF-kB, COX-2, cyclin B, p-CDC2 | |
| Gene or Protein evidence | FK-3000 suppressed NF-kB nuclear translocation, decreased NF-kB phosphorylation, and decreased COX-2 protein expression. Conclusively FK-3000 exerts its antiproliferative effect through two pathways: i) G2/M cell cycle arrest via downregulation of cyclin B and phospho-CDC2 by p38 MAPK phosphorylation and CDC25B dephosphorylation, and ii) p38 MAPK-independent induction of apoptosis. | |
| Target pathways | NF-kB-COX-2 pathway | |
| IC50 | 0.52 µg/ml against MDA-MB-231 0.77 µg/ml against MCF-7 | |
| Potency | The FK-3000 half maximal inhibitory concentration (IC50) in MDA-MB-231 breast carcinoma cells at 48 h was 0.52 µg/ml and it induced apoptosis in a dose- and time-dependent manner. | |
| Cell line/ mice model | MDA-MB-231 xenografted mice, MCF-7, MDA-MB-231, PC-3, HT-29 | |
| Additional information | The tumor size was smallest in the co-treatment group, indicating that FK-3000 may have a synergistic effect with Taxol. FK-3000 treatment showed no adverse effects on blood cell counts, serum protein levels, or pathology. | |
| PubChem ID | 9823255 | |
| Additional PMIDs | 25384584 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:581412-1 | |
| Safety | These studies demonstrate that FK-3000, isolated from S. delavayi Diels., is a promising, pathway-specific anticancer agent that exhibits low toxicity. |