| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-111 | |
| Phytochemical name or plant extracts | 5,7-Dimethoxyflavone | |
| PMID | 29425861 | |
| Literature evidence | Our results indicated that 5,7-DMF may represent a novel and very promising chemosensitizing agent for BCRP-mediated anticancer drug resistance due to its low toxicity and potent BCRP inhibition. | |
| IUPAC name | 5,7-dimethoxy-2-phenylchromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Anaphalis busua | |
| Geographical availability | Assam, China South-Central, East Himalaya, India, Myanmar, Nepal, Pakistan, Tibet, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | 5,7-DMF significantly inhibited Bcrp1-mediated sorafenib efflux in a concentration dependent manner in MDCK/Bcrp1 cells, with EC50 value of 8.78 μM. | |
| Cell line/ mice model | MDCK/Bcrp1 | |
| Additional information | Our results indicated that 5,7-DMF may represent a novel and very promising chemosensitizing agent for BCRP-mediated anticancer drug resistance due to its low toxicity and potent BCRP inhibition. | |
| PubChem ID | 88881 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:176384-1 | |
| Safety | NA |