| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-428 | |
| Phytochemical name or plant extracts | 5,7,3',4'-tetrahydroxyisoflavone (THIF) | |
| PMID | 17976513 | |
| Literature evidence | This may represent one mechanism by which genistein exerts its cellular activity in vivo. | |
| IUPAC name | 3-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Ammopiptanthus mongolicus | |
| Geographical availability | China North-Central, Inner Mongolia, Mongolia, Xinjiang | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | cdc2, Chk1, p53 | |
| Gene or Protein evidence | THIF treatment also led to an inhibition of cdc2, which was accompanied by the phosphorylation of both p53 (Ser15) and Chk1 (Ser296) and the de-activation of cdc25C phosphatase. | |
| Target pathways | 5,7,3',4'-tetrahydroxyisoflavone (THIF), induced G2-M cell cycle arrest in T47D tumorigenic breast epithelial cells via a mechanism involving the activation of ataxia telangiectasia and Rad3-related kinase (ATR) via its phosphorylation at Ser428. | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | T47D | |
| Additional information | NA | |
| PubChem ID | 5281801 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:473740-1 | |
| Safety | NA |