| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-51 | |
| Phytochemical name or plant extracts | 5,3′-dihydroxy-6,7,8,4′-tetramethoxyflavanone (HLBT-100) | |
| PMID | 28286420 | |
| Literature evidence | Despite significant efforts to discover and develop novel anticancer agents, many cancers remain in the unmet need category. | |
| IUPAC name | 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7,8-trimethoxy-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Tillandsia recurvata | |
| Geographical availability | Argentina Northeast, Argentina Northwest, Arizona, Aruba, Bahamas, Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Cayman Is., Chile North, Colombia, Cuba, Dominican Republic, Ecuador, El Salvador, Florida, Georgia, Guatemala, Haiti, Honduras, Jamaica, Leeward Is., Louisiana, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Netherlands Antilles, New Mexico, Nicaragua, Paraguay, Peru, Puerto Rico, Texas, Turks-Caicos Is., Uruguay, Venezuela, Venezuelan Antilles, Windward Is. | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Brain cancer, melanoma, Leukemia | |
| Target gene or protein | Caspase 3, Caspase 7 | |
| Gene or Protein evidence | In terms of potential mechanisms of action, the molecule demonstrated effect on the cell cycle as evidenced by the accumulation of cells with <G1 DNA content, activation of caspase 3/7, DNA fragmentation and culminating in apoptotic cell death. | |
| Target pathways | NA | |
| IC50 | 0.030 µM against MDA-MB-231 | |
| Potency | Twenty-three of the NCI60 cell lines were inhibited with GI50 values <0.100 µM. | |
| Cell line/ mice model | U87 MG, MDA-MB-231, MV4-11, A375, IMR-32 | |
| Additional information | HLBT-100 also demonstrated antiangiogenic potential by inhibiting capillary sprout and tube formation in a dose dependent manner in the ex vivo rat aortic ring. | |
| PubChem ID | 91535337 | |
| Additional PMIDs | 24564035 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1194855-2 | |
| Safety | NA |